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IMMUNE PROTECTION AGAINST ENTEROTOXINOGENIC E. COLI: SEARCH FOR SYNERGY BETWEEN ANTIBODIES TO ENTEROTOXIN AND SOMATIC ANTIGENS
Author(s) -
Svennerholm A.M.,
Åhrén C.
Publication year - 1982
Publication title -
acta pathologica microbiologica scandinavica series c: immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0202
DOI - 10.1111/j.1699-0463.1982.tb01409.x
Subject(s) - enterotoxin , antiserum , heterologous , antibody , microbiology and biotechnology , antigen , escherichia coli , lipopolysaccharide , immune system , serotype , cholera toxin , biology , toxin , chemistry , immunology , biochemistry , gene
The protective effect against intestinal challenge with enterotoxinogenic (ent +) E. coli of enterotoxin antibodies alone and in combination with various antibacterial antibodies has been studied in rabbits. Both antibodies against E. coli heat‐labile enterotoxin (LT) and cholera toxin were equally effective against different serotypes of ent+ E. coli. Antiserum to purified homologous E. coli lipopolysaccharide (LPS) as well as to cross‐reactive LPS structures (Re LPS and Common antigen) contained protective antibodies which increased the protection obtained with anti‐enterotoxin. Antiserum to whole bacteria acted synergistically with anti‐LT against homologous and sometimes also against heterologous E. coli . This synergy remained after complete absorption of the LPS antibodies from the antibacterial serum.