Premium
HISTOPATHOLOGICAL SUBGROUPING OF WHO II UROTHELIAL NEOPLASMS BY CYTOPHOTOMETRIC MEASUREMENTS OF NUCLEAR ATYPIA
Author(s) -
HERDER A.,
BJELKENKRANTZ K.,
GRÖNTOFT O.
Publication year - 1982
Publication title -
acta pathologica microbiologica scandinavica series a :pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0164
DOI - 10.1111/j.1699-0463.1982.tb00114_90a.x
Subject(s) - atypia , nuclear atypia , pathology , feulgen stain , significant difference , biology , medicine , staining , immunohistochemistry
The grade of nuclear atypia was objectively assessed in 21 cases of non‐invasive WHO II transitional cell bladder neoplasm. Measurements were performed by stage scanning absorbance cytophotometry, registering nuclear optical density, nuclear area, and the variability of these two factors, in 5 μm thick Feulgen‐stained paraffin sections. The material was subgrouped into a 2‐ and a 2+ group according to the degree of histopathological atypia. Cytophotometrically determined atypia showed close correlation to the subjectively judged atypia, and there was no overlap between 2‐ and 2+. A difference in tumour ploidy level between different WHO II tumours is the most likely explanation of the grouping recorded.