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CARCINO‐EMBRYONIC ANTIGEN (CEA) IN GASTRIC ADENOCARCINOMAS
Author(s) -
NIELSEN KARSTEN,
TEGLBJÆRG PETER STUBBE
Publication year - 1982
Publication title -
acta pathologica microbiologica scandinavica series a :pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0164
DOI - 10.1111/j.1699-0463.1982.tb00112_90a.x
Subject(s) - immunoperoxidase , cytoplasm , pathology , adenocarcinoma , carcinoembryonic antigen , cell type , glycocalyx , antigen , cell , cancer , biology , chemistry , medicine , antibody , immunology , microbiology and biotechnology , monoclonal antibody , genetics
The presence of carcino‐embryonic antigen (CEA) was studied in 92 consecutive cases of gastric adenocarcinoma, using the two‐layer conjugated immunoperoxidase technique. Three characteristic patterns of CEA localization were identified. Type I : Intracytoplasmatic granules covering the entire cytoplasm of the malignant cells. Type II. Linear or granular deposits along the glycocalyx or in the apical cytoplasm of the malignant cells. Type III : Tumour cells negative for CEA or only showing a very weak reaction in a few cells. These CEA patterns were significantly related to the histogenetic classification of gastric adenocarcinomas proposed by Mulligan & Rember. The majority of the »mucus cell carcinomas« showed the type I CEA pattern. »Intestinal cell carcinomas« predominantly showed the type II CEA pattern and the »pylero‐cardiac gland carcinomas« the type III CEA pattern. The significance of the CEA patterns in respect of the histogenetic classification is discussed.