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RESISTANCE TYPES IN ENTEROBACTER CLOACAE
Author(s) -
SØGAARD PER
Publication year - 1982
Publication title -
acta pathologica microbiologica scandinavica series b: microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0180
DOI - 10.1111/j.1699-0463.1982.tb00110.x
Subject(s) - carbenicillin , ampicillin , enterobacter cloacae , mecillinam , amp resistance , microbiology and biotechnology , streptomycin , enterobacter , penicillin , biology , antibiotics , escherichia coli , enterobacteriaceae , genetics , gene
An investigation of the resistance types in Enterobacter cloacae is presented. The frequency of the different resistance types was determined. The strains were divided into three groups according to sensitivity to penicillin derivatives. The ampicillin‐carbenicillin‐sensitive (A‐s/Ca‐s) group 1 comprised 20 % of the E. cloacae strains received in this laboratory. The ampicillin resistant‐carbenicillin‐sensitive (A‐r/Ca‐s) group 2 comprised 38.596 of the strains and the A‐r/Ca‐r group 3 comprised 41.5% of the strains. Group 3 contained a high proportion of multi‐resistant strains. The log 2 IC 50 against ampicillin, carbenicillin, cephalothin and mecillinam was determined for 28 strains. The group 3 strains were more ampicillin‐resistant than the group 2 ones. Group 1 and 2 did not differ as regards carbenicillin sensitivity. The cephalothin resistance increased from group 1 to group 2 and further on to group 3. Mecillinam sensitivity did not differ between the three groups. The ability to transfer ampicillin resistance was investigated in the 24 A‐r strains. The 8 group 2 strains were not able to transfer resistance, while 9 of 16 strains in group 3 could transfer A‐resistance with frequencies ranging from 10 ‐0.2 to 10 ‐5.7 . Resistance to sulphonamide, tetracyline and streptomycin was also transferred, often with the same frequency as the ampicillin resistance.