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LONG‐TERM ORAL CANDIDOSIS IN RATS
Author(s) -
FISKER A. V.,
SCHIØTT C. RINDOM,
PHILIPSEN H. P.
Publication year - 1982
Publication title -
acta pathologica microbiologica scandinavica series b: microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0180
DOI - 10.1111/j.1699-0463.1982.tb00109.x
Subject(s) - acanthosis , tongue , candida albicans , epithelium , oral mucosa , cheek , hyperplasia , hyperkeratosis , medicine , gingival margin , pathology , stomatitis , biology , dentistry , dermatology , anatomy , microbiology and biotechnology
The aim of the study was to investigate the carriage and infection rate during continuous oral inoculation of Candida albicans in conventionalized SPF rats after initial tetracycline medication. During the 34‐week experiment 50% of the animals harboured Candida albicans in the mouth, whereas only 25 % of the animals demonstrated pseudomycelial penetration of the oral mucosa. More than ninety per cent of the candidal foci were found in areas covered by a less densely cornified epithelium and were mainly localized to the sulcular folds, the gingival margin and the cheek. Only the dorsal surface of the tongue showed foci with obvious signs of long‐standing candidal infection. The lingual papillae were lost and replaced by a flat‐surfaced parakeratotic epithelium showing irregular hyperplasia, acanthosis but no atypia. Reactive changes were found in the underlying lingual muscular layer.