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ALVEOLAR RHABDOMYOSARCOMA: A CYTOGENETIC AND CORRELATED CYTOLOGICAL AND HISTOLOGICAL STUDY
Author(s) -
SEIDAL T.,
MARK J.,
HAGMAR B.,
ANGERVALL L.
Publication year - 1982
Publication title -
acta pathologica microbiologica scandinavica series a :pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0164
DOI - 10.1111/j.1699-0463.1982.tb00105_90a.x
Subject(s) - pathology , karyotype , rhabdomyosarcoma , giant cell , alveolar rhabdomyosarcoma , multinucleate , biology , cytology , sarcoma , cytoplasm , embryonal rhabdomyosarcoma , chromosome , anatomy , medicine , microbiology and biotechnology , genetics , gene
A correlative, histologic and cytologic study of seven cases of alveolar rhabdomyosarcoma and chromosome analysis using the G‐banding technique (in case 1) is presented. The histologic pattern was characterized by pseudo‐alveolar structures, separated by fibrous septa. Primitive, dark, round cells predominated, but differentiated rhabdomyoblasts were found in all cases, and so were multi‐nucleated giant cells. Unequivocal cross striation was seen in two cases. Cytologically, the tumors were highly cellular and small, undifferentiated tumor cells predominated. Large polymorphous, sometimes multinucleated, cells often with an elongated cytoplasm and eccentric nucleus were observed in all cases. The cell‐types found could be well correlated to those identified in the histologic sections. The cytogenetic study revealed a karyotype profile, showing three 2q markers and only one chromosome type No. 13. The observations are different from the karyotype profile of embryonal rhabdomyosarcoma. However, further studies are necessary to elucidate this question.