Premium
INCREASED SUSCEPTIBILITY OF HYPERSPLENIC RATS TO INFECTION WITH PNEUMOCOCCI
Author(s) -
ALWMARK ANDERS,
CHRISTENSEN POUL,
GULLSTRAND PER,
SCHALÉN CLAËS
Publication year - 1982
Publication title -
acta pathologica microbiologica scandinavica series b: microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0180
DOI - 10.1111/j.1699-0463.1982.tb00094.x
Subject(s) - hematocrit , spleen , hemoglobin , streptococcus pneumoniae , medicine , platelet , splenectomy , immunology , biology , microbiology and biotechnology , antibiotics
Hypersplenism was induced in rats by intra‐peritoneal injections of methylcellulose. These rats developed an outsize spleen and had significantly depressed values for hemoglobin concentration, hematocrit and platelet count. The rats given methylcellulose were also found to be more susceptible to a challenge with a standardized intravenous injection of Streptococcus pneumoniae and had a significantly higher mortality rate than the control rats.