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THE LUKES AND COLLINS CLASSIFICATION OF NON‐HODGKIN'S LYMPHOMAS
Author(s) -
AINE RISTO,
ALAVAIKKO MARTTI,
KATAJA MATTI
Publication year - 1982
Publication title -
acta pathologica microbiologica scandinavica series a :pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0164
DOI - 10.1111/j.1699-0463.1982.tb00089_90a.x
Subject(s) - lymphoma , medicine , working formulation , hodgkin lymphoma , sarcoma , follicular phase , non hodgkin's lymphoma , pathology , oncology , gastroenterology
In a retrospective study of 301 non‐Hodgkin's lymphoma patients the clinical and prognostic value of the classification of Lukes and Collins was studied. A slight majority of the cases were of the follicular center cell types. Stages III‐IV were found in 46% of the entire group at the time of diagnosis. The lymphomas showing follicular center cell types were frequently localized (63%). About 65% of all cases survived one year and about 45% five years. The females showed a better survival. The nodal lymphoma cases had the poorest survival. Two prognostically different subgroups of non‐Hodgkin's lymphomas were discerned. The more favourable group consisted of the small cleaved FCC type (five‐year relative survival 74%), the small lymphocytic type (62%) and the plasmacytoid lymphocytic type (51%). The small non‐cleaved FCC type, the large non‐cleaved FCC type and the immunoblastic sarcoma type formed the other group with a less favourable prognosis. Mortality due to these types manifested itself to a level of 65% in the first two years.