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OSTEOSCLEROSIS OF THE FEMORAL HEAD IN LONG‐TERM URAEMIC RABBITS
Author(s) -
TVEDEGAARD ERLING,
NIELSEN MAJA,
KAMSTRUP OLE
Publication year - 1982
Publication title -
acta pathologica microbiologica scandinavica series a :pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0164
DOI - 10.1111/j.1699-0463.1982.tb00087_90a.x
Subject(s) - osteosclerosis , medicine , femoral head , resorption , osteoid , bone resorption , skeleton (computer programming) , osteoporosis , pathology , anatomy
The morphology of the femoral head of rabbits was studied by histomorphometric analysis of undecalcified sections after four and eight months' duration of surgically induced chronic renal failure. A significant increase in trabecular bone mass and osteoid tissue was found in the uraemic rabbits. Signs of osteonecrosis or increased bone resorption were not seen. 99m Technetium‐methylenediphosphonate osteoscintigrams showed increased uptake in the axial skeleton and all periarticular regions in uraemic rabbits. The serum concentrations of calcium and phosphate in the uraemic rabbits were increased.