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IMMUNOHISTOLOGICAL STUDIES ON VALVULAR VEGETATIONS IN NONBACTERIAL THROMBOTIC ENDOCARDITIS (NBTE)
Author(s) -
LEHTO V.P.,
STENMAN S.,
SOMER T.
Publication year - 1982
Publication title -
acta pathologica microbiologica scandinavica series a :pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0164
DOI - 10.1111/j.1699-0463.1982.tb00083_90a.x
Subject(s) - thrombus , endocarditis , autopsy , pathogenesis , pathology , immunofluorescence , antibody , medicine , complement system , mechanical heart , immunology , cardiology
Thrombi and thrombus formation in nonbacterial thrombotic endocarditis (NBTE) were studied using light microscopy and immunohistology. Samples from vegetations on cardiac valves were taken at autopsy from five patients with NBTE and adenocarcinoma as an underlying disease. Morphological studies disclosed proliferative changes underneath the thrombi. In immunofluorescence microscopy, focal deposits of immunoglobulins and complement components C1q and C3 were found. The results suggest that immune complexes, elicited by the underlying malignant process, may play important role in the pathogenesis of the thrombus formation in NBTE.