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Clq BINDING AND COMPLEMENT ACTIVATION BY CAPSULAR AND CELL WALL COMPONENTS OF S. PNEUMONIAE TYPE XIX
Author(s) -
PRELLNER KARIN
Publication year - 1981
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1981.tb02713.x
Subject(s) - teichoic acid , cell wall , alternative complement pathway , egta , activator (genetics) , chemistry , biochemistry , antibody , cell , complement c1q , complement system , biology , receptor , immunology , peptidoglycan , organic chemistry , calcium
Cell wall components (purified cell walls, teichoic acid and residual cell walls) from S. pneumoniae type XIX showed antibody independent Clq binding capacity, as assessed by Clq deviation test, with teichoic acid being the most efficient. Specific capsular substance did not bind Clq. All substances tested produced CI activation in normal human serum, but not in hypo‐y‐globulinemic serum. Thus, teichoic acid showed high Clq binding capacity but did not activate CI in the absence of antibodies. Teichoic acid was an effective activator of the alternative pathway. Specific capsular substance did not activate the alternative pathway in Clq deficient serum or in Mg 2+ ‐EGTA chelated normal serum.