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ANTIBODIES TO STAPHYLOCOCCAL LIPOTEICHOIC ACID IN SERUM AND IN CEREBROSPINAL FLUID FROM PATIENTS WITH MULTIPLE SCLEROSIS
Author(s) -
AASJORD PER,
NYLAND HARALD
Publication year - 1981
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1981.tb02709.x
Subject(s) - cerebrospinal fluid , antibody , lipoteichoic acid , multiple sclerosis , agarose , immunology , staphylococcus aureus , chemistry , medicine , microbiology and biotechnology , pathology , bacteria , biology , chromatography , genetics
Antibodies to staphylococcal lipoteichoic acid (LTA) were determined in serum and in cerebrospinal fluid (CSF) from a group of patients with multiple sclerosis (MS) and a group of healthy individuals. Sera from 11 out of 74 MS patients, i.e. 15 percent, contained precipitating antibodies demonstrated by the double diffusion in agar test, compared to 48 out of 94 control sera, i.e. 51 per cent. By using an indirect haemagglutination test, antibodies to LTA were found in all sera from both patients and controls. On the other hand, LTA antibodies were detected in a higher proportion of the CSF samples from MS patients than from controls. A reduced serum to CSF ratio of LTA antibodies compared with the ratio for a reference antibody was demonstrated in 7 out of 20 MS patients, suggesting a local synthesis within the central nervous system. Absorption of seven MS CSF samples with LTA removed one to three of the cathodic oligoclonal IgG bands demonstrated by agarose electrophoresis and reduced the IgG concentration.