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INFLUENCE OF IN VIVO HYDROCORTISONE ON SOME HUMAN BLOOD LEUCOCYTE SUB‐POPULATIONS
Author(s) -
ONSRUD M.
Publication year - 1981
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1981.tb02707.x
Subject(s) - in vivo , stimulation , hydrocortisone , in vitro , antigen , immunology , cell , medicine , pharmacology , biology , chemistry , endocrinology , biochemistry , microbiology and biotechnology
The effect of in vivo hydrocortisone (OHO on various in vitro T cell responses was studied in five volunteers. Four hours after the administration of 300 mg OHC intravenously, the T cell response to soluble antigen (PPD) was only slightly depressed ‐ as was the response to alloantigen ‐ whereas the T cell response to autologous non‐T cells was nearly abolished. In vivo OHC caused a profound depression of the number of circulating monocytes, but those still remaining in circulation had retained their antigen presenting capacity. In vitro OHC‐treatment for four hours prior to PPD stimulation did not affect the antigen presenting capability of monocytes or the proliferative responsiveness of T Cells.