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IN VITRO CYTOTOXICITY OF LYMPHOCYTE SUBPOPULATIONS AGAINST AUTOLOGOUS HUMAN BLADDER TUMOR CELLS
Author(s) -
JACOBSEN FLEMMING
Publication year - 1981
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1981.tb02694.x
Subject(s) - cytotoxicity , cytotoxic t cell , in vitro , lymphocyte , effector , immunology , t lymphocyte , cancer research , biology , medicine , microbiology and biotechnology , immune system , biochemistry
The in vitro cytotoxicity of unfractionated blood lymphocytes and T and non‐T lymphocytes respectively, was tested against autologous tumor cells from 21 patients with grade III‐IV urothelial bladder carcinomas. Generally, little or no cytotoxicity was seen. However, some differences in autologous cytotoxicity between T and non‐T lymphocytes were detectable. Four of 21 patients had cytotoxic non‐T lymphocytes against autologous bladder tumor cells. The results indicate, that the effector cells are primarily non‐T lymphocytes, and that cytotoxicity appears at lower levels of T lymphocytes in unfractionated lymphocyte preparations.