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GENERAL PARALYSIS OF THE INSANE ASSOCIATED WITH HLA‐Aw32
Author(s) -
PEDERSEN N. STRANDBERG,
AXELSEN N. H.,
SVEJGAARD A.
Publication year - 1981
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1981.tb02683.x
Subject(s) - neurosyphilis , dementia , paralysis , human leukocyte antigen , syphilis , medicine , psychology , pediatrics , immunology , psychiatry , disease , antigen , human immunodeficiency virus (hiv)
HLA‐A, ‐B, and ‐C locus antigens were determined in 35 unrelated patients with general paralysis of the insane (GPI), and in 13 neurosyphilis patients without dementia. HLA‐Aw32 was found more frequently (corrected p = 4.9 × 10 −2 ) in the GPI patients than in 1009 controls. None of the patients having neurosyphilis without dementia had HLA‐Aw32. These findings indicate that genetically determined mechanisms may play a role in development of GPI. Further studies of such rare patients should be initiated to investigate whether these observations reflects a true association or whether they are due to chance. If possible other well defined groups of tertiary syphilis should also be studied.