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AUGMENTATION OF HUMAN LYMPHOCYTE PROLIFERATIVE RESPONSES IN VITRO BY PYRIMETHAMINE
Author(s) -
BYGBJERG IB CHRISTIAN
Publication year - 1981
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1981.tb02673.x
Subject(s) - phytohaemagglutinin , pyrimethamine , pokeweed mitogen , peripheral blood mononuclear cell , in vitro , immunology , pharmacology , thymidine , lymphocyte , medicine , biology , virology , plasmodium falciparum , malaria , biochemistry
Thymidine incorporation by human blood mononuclear cells, unstimulated and stimulated with phytohaemagglutinin (PHA), pokeweed mitogen (PWM) and purified protein derivate of tuberculin (PPD) was studied with and without addition of pyrimethamine. Responses were increased significantly by pyrimethamine in the PWM and PPD stimulated cultures, in the PPD cultures even by concentrations of pyrimethamine, which can be achieved with therapeutic doses of this drug. The closely related compound trimethoprim did not alter PHA‐, PWM‐ and PPD‐responses significantly. The possibility of using pyrimethamine ‐ a widely used prophylactic antimalarial ‐ as an immunopotentiator is mentioned.