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ENHANCING EFFECT OF SURGICAL BURSECTOMY ON ANTIBODY RESPONSE
Author(s) -
HIROTA YOSHIKAZU,
VAINIO OLLI,
TOIVANEN PAAVO
Publication year - 1981
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1981.tb02662.x
Subject(s) - bursectomy , priming (agriculture) , brucella abortus , antibody response , antibody titer , titer , bursa of fabricius , antigen , antibody , immunology , biology , immune system , botany , germination , brucellosis
Effect of surgical bursectomy on antibody response was studied in chicks injected intrabursally with sheep red blood cells (SRBC) and Brucella abortus on day 2 of life and challenged intravenously with the same antigens on day 9. Bursectomy performed 2 days after the priming resulted in a significantly decreased anti‐SRBC plaque‐forming cell (PFC) response, whereas bursectomy performed 4 or 5 days after the priming clearly enhanced the PFC response. The enhancing effect of bursectomy on the PFC response was also observed if the priming was made intravenously. In antibody titers against SRBC the enhancing effect was observed only if a secondary and tertiary challenge was performed at the age of 28 and 36 days, respectively. Titers of Brucella antibodies were either reduced by the bursectomy (performed 2 or 4 days after the intrabursal priming) or left unaffected (bursectomy performed 5 days after the priming). These findings are discussed in relation to bursa‐derived suppressor cells.