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HISTOLOGICAL STUDIES OF SMALL‐INTESTINAL BIOPSIES FROM INFANTS WITH LOW RATE OF WEIGHT GAIN
Author(s) -
FÄLLSTRÖM S. P.,
KRISTIANSSON B.,
RYD W.
Publication year - 1981
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1981.tb00242.x
Subject(s) - weight gain , medicine , pathology , body weight
Eighty‐one children aged 4–18 months with unsatisfactory weight gain were investigated for organic diseases; the investigation included small‐intestinal biopsy. Sixteen had total villous atrophy, in most cases due to gluten intolerance. Transient disease, e.g. cow's milk protein intolerance, was probable in 7 children with subtotal atrophy. In 18 children the only abnormal finding was an increased number of inflammatory cells in the mucosa, a finding which was probably of no clinical significance. Planimetric measurement showed good agreement between the mucosal surface/volume ratio and an ordinary histological grouping of the mucosa. A significant correlation was found between the rate of weight gain during the period preceding investigation and mucosal surface/volume ratio.