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CLINICAL AND MORPHOLOGICAL FINDINGS IN TWO CASES OF BROMOCRIPTINE‐TREATED PROLACTINOMAS
Author(s) -
ANNIKO MATTI,
WERSÄLL JAN
Publication year - 1981
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1981.tb00185.x
Subject(s) - bromocriptine , prolactin , adenoma , morphology (biology) , pituitary adenoma , in vitro , pathology , tumor cells , hormone , cell , biology , endocrinology , medicine , cancer research , biochemistry , zoology
The morphology of two cases of prolactin (PRL) secreting pituitary tumours was analyzed at the light and electron microscopic level. Prior to surgery both patients had been treated with bromocriptine. In both tumours, groups of cells revealed considerable morphological changes but these were not confined to the whole adenoma. In fact, most cells still appeared ultrastructurally intact. Pieces from both adenomas were explanted to an in vitro system. These specimens secreted mainly PRL though smaller amounts of growth hormone (GH) were also produced. The cell morphology of the cultured specimens often showed a large number of preserved cells.