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ULTRASTRUCTURE OF THE AORTIC INTIMA IN FOCAL AREAS OF INTRAVITAL EVANS BLUE UPTAKE IN THE RABBIT
Author(s) -
KJELDSEN KNUD,
THOMSEN HENRIK KLEM
Publication year - 1981
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1981.tb00179.x
Subject(s) - evans blue , ultrastructure , pathology , hemodynamics , rabbit (cipher) , pathological , anatomy , biology , medicine , statistics , mathematics
Ultrastructural morphology of the rabbit aortic intima is described for areas demarcated or not demarcated by spontaneous in vivo uptake of the azo dye Evans Blue. Intimal foci taking up Evans Blue are characterized by endothelial and subendothelial cells showing various degrees of degenerative changes, appearance of young cells and subendothelial fibromuscular thickening. It is concluded that dye uptake is a marker for regions subjected to hemodynamic ‘stress’ due to turbulence or increased flow load, and that the morphologic changes in normal animals are part of appropriate regeneration processes which keep the artery functionally intact. Such foci may represent predilection areas for atherogenesis in pathological situations, such as hypertension or hypercholesterolemia.