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AMPICILLIN TREATMENT OF NEISSERIA GONORRHOEAE IN VIVO
Author(s) -
ELMROS THEODOR,
HOLM STIG E.,
KJELLBERG ERIK,
WINBLAD BENGT
Publication year - 1981
Publication title -
acta pathologica microbiologica scandinavica section b microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-131X
DOI - 10.1111/j.1699-0463.1981.tb00167_89b.x
Subject(s) - ampicillin , neisseria gonorrhoeae , in vivo , chemistry , microbiology and biotechnology , population , antibiotics , biology , medicine , environmental health
The effect of ampicillin on gonococci was investigated in chambers subcutaneously implanted in rabbits. An intramuscular injection of ampicillin resulted in a rapid increase of the ampicillin concentration in serum, whereas the diffusion of ampicillin into the fluid of a non‐infected chamber was comparatively slow. The ampicillin concentration was, however, maintained in the chamber fluid during a prolonged period of time as compared to ampicillin in serum. The concentration profile of ampicillin in the infected chamber was similar to that of the non‐infected chamber, though at a lower level. No viable gonococci were detected 120 minutes after the injection of ampicillin. In contrast, the same concentration of ampicillin in a liquid culture resulted in slower reduction in the viability of the gonococcal strain. Even after 300 minutes a small population of gonococci was viable. Thus, a difference in the activity of ampicillin could be observed between the in vitro and the in vivo test situation.