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EFFECTS OF ANTIBACTERIAL AGENTS ON THE ELIMINATION OF 32 P‐LABELLED ESCHERICHIA COLI BY HUMAN POLYMORPHONUCLEAR CELLS (PMN)
Author(s) -
Melby Kjetil,
Midtvedt Tore
Publication year - 1981
Publication title -
acta pathologica microbiologica scandinavica section b microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-131X
DOI - 10.1111/j.1699-0463.1981.tb00164_89b.x
Subject(s) - chloramphenicol , escherichia coli , doxycycline , trimethoprim , colistin , microbiology and biotechnology , chemistry , gentamicin , oxytetracycline , erythromycin , antibiotics , biology , biochemistry , gene
Eight antibacterial agents, cephalothin, colistin, doxycycline, erythromycin, gentamicin, chloramphenicol, oxytetracycline and trimethoprim were studied in a phagocytic system using human polymorphonuclear cells (PMN) and a radio‐labelled strain of Escherichia coli as test microbe. 100 μg/ml of either doxycycline or trimethoprim appeared to reduce the elimination of labelled products from the PMN. The effect of doxycycline was independent of heat‐labile serum factors.