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ANTIBODIES TO THE STRAIN‐SPECIFIC AND CROSS‐REACTIVE DETERMINANTS OF THE HAEMAGGLUTININ OF INFLUENZA H3N2 VIRUSES.
Author(s) -
Haaheim Lars R.
Publication year - 1980
Publication title -
acta pathologica microbiologica scandinavica section b microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-131X
DOI - 10.1111/j.1699-0463.1980.tb02653.x
Subject(s) - antibody , virology , antigen , virus , biology , original antigenic sin , strain (injury) , in vitro , antigenic drift , hemagglutinin (influenza) , immune system , in vivo , microbiology and biotechnology , immunology , biochemistry , anatomy
Antigenic variants of influenza A/Hong Kong/1/68 (H3N2) were obtained in vitro by letting virus multiply in the allantois‐on‐shell system in the presence of anti‐haemagglutinin antibodies, prepared from immune goat serum to purified haemagglutinin antigen, and in vivo by giving mice antibody intraperitoneally one day before challenge with a sublethal dose of live virus. In both systems it was shown that the most narrowly reacting strain‐specific antibodies selected antigenic variants at an apparently higher rate than a more cross‐reactive preparation of antibodies.