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ANTIBIOTIC SENSITIVITY OF ENTEROPATHOGENIC ESCHERICHIA COLI TO MECILLINAM, TRIMETHOPRIM‐SULFAMETHOXAZOLE AND OTHER ANTIBIOTICS
Author(s) -
ThoréN Anders
Publication year - 1980
Publication title -
acta pathologica microbiologica scandinavica section b microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-131X
DOI - 10.1111/j.1699-0463.1980.tb02639.x
Subject(s) - mecillinam , microbiology and biotechnology , ampicillin , sulfamethoxazole , antibiotics , trimethoprim , nalidixic acid , sulfisoxazole , microgram , streptomycin , gentamicin , serotype , escherichia coli , biology , chemistry , enterobacteriaceae , tetracycline , in vitro , biochemistry , gene
Forty‐six clinical isolates of enteropathogenic Escherichia coli (EPEC) collected in Addis Ababa, Ethiopia, 1977–1978, were tested for susceptibility to 12 different antibiotics and beta‐lactamase‐production. Special reference was made to mecillinam and trimethoprim‐sulfamethoxazole (TMP‐SMZ) that were recently shown to be effective in the treatment of severe gastroenteritis caused by EPEC. Twenty‐nine of the strains were of serotype 0111:B4. Thirty of the strains were resistant to 4 antibiotics or more, most of these strains belonging to serotype 0111:B4. For mecillinam, 19 strains had minimal inhibitory concentration (MIC) 0.2 μg/ml, 27 strains had MIC 0.8–3.2 μg/ml. Regarding TMP‐SMZ, 41 strains had MIC 1 μg/ml, 5 strains had 2–4 μg/ml. No strain was resistant to gentamicin or nalidixic acid. Increased production of beta‐lactamase was correlated to ampicillin resistance.