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THE ANTRAL GASTRIN‐PRODUCING CELLS IN DUODENAL ULCER PATIENTS
Author(s) -
NIELSEN H. OVERGAARD,
JENSEN K. BIRGER,
CHRISTIANSEN L. A.
Publication year - 1980
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1980.tb02510.x
Subject(s) - gastrin , discontinuation , cimetidine , medicine , hyperplasia , g cell , gastroenterology , antrum , histamine , endocrinology , stomach , secretion
A density study of the antral gastrin‐producing cells has been performed, before and after eight weeks of treatment with a histamine H 2 ‐receptor antagonist (cimetidine 1 g per day), in a series of 38 patients suffering from chronic duodenal ulcer. The treatment produced a significant increase in numerical density and a decrease in mean cell volume. The volume density of the cells was unchanged, suggesting that the elevated serum‐gastrin during treatment may be the result of gastrin‐cell hyperplasia, without change in the total gastrin‐cell volume. The authors suggest that G‐cell hyperplasia demonstrated during cimetidine treatment may be a factor of importance with regard to the rapid recurrence of many ulcers after discontinuation of the treatment.