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IMMUNOCYTOCHEMICAL DEMONSTRATION OF ENKEPHALIN AND β‐ENDORPHIN IN ENDOCRINE TUMORS OF THE RECTUM
Author(s) -
ALUMETS J.,
FALKMER S.,
GRIMELIUS L.,
HÅKANSON R.,
LJUNGBERG O.,
SUNDLER F.,
WILANDER E.
Publication year - 1980
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1980.tb02473.x
Subject(s) - argentaffin , rectum , enteroendocrine cell , pathology , enkephalin , lymph node , medicine , pancreatic polypeptide , biology , endocrine system , glucagon , hormone , receptor , opioid
In a histopathological and immunocytochemical study of biopsy and/or operation specimens from 27 patients with endocrine tumors of the colon and rectum (»hind‐gut carcinoids«) enkephalin‐immunoreactive tumor cells were observed in two cases. Both patients were obese women, about 50 years of age, with a history of constipation. The tumors were situated near the anus in the dorsal wall of the rectum. One tumor had metastasized to a lymph node, and the other showed vascular invasion. The tumor cells were non‐argentaffin; some were argyrophil. One tumor contained only few enkephalinimmunoreactive cells but had numerous β‐endorphin‐immunoreactive cells, which were distinct from the former. The other contained large numbers of enkephalin‐immunoreactive cells but no β‐endorphin cells. Both tumors also harboured glucagon‐immunoreactive cells; in one there were also cells containing immunoreactive pancreatic polypeptide. These cells were distinct from the enkephalin‐storing ones. No 5‐hydroxytryptamine could be detected in the two tumors.