Premium
IgG AND OTHER PROTEINS ASSOCIATED WITH HUMAN CARCINOMAS AND CANCER‐FREE TISSUE FROM THE SAME ORGANS
Author(s) -
WESENBERG FINN,
TÖNDER OLAV
Publication year - 1980
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1980.tb00112.x
Subject(s) - kidney , cancer , liver cancer , albumin , pathology , liver tissue , kidney cancer , antigen , medicine , tumour tissue , carcinoma , immunology
Eluates of different tissues were prepared at 56°C using a continuous flow technique. More IgG and other serum proteins were found in liver tissue from patients with non‐malignant diseases than in liver tissue from healthy control individuals. Cancer‐free liver tissue from patients with carcinomas was similar to that of patients with non‐malignant diseases, but liver metastases contained twice the amount of IgG. No differences were found between non‐perfused carcinomas of the kidney and cancer‐free renal tissue, whereas more IgG was present in perfused carcinomas of the kidney than in cancer‐free renal tissue. Most eluates of the malignant tissues and of the cancer‐free renal tissue showed a reduced ratio of albumin to IgG compared to that of serum or extracts, indicating a binding of IgG to antigens and/or receptors.