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COMMON VARIABLE IMMUNODEFICIENCY AND PURINE NUCLEOTIDASE AND NUCLEOSIDE PHOSPHORYLASE DEFICIENCY
Author(s) -
ØSTERGAARD POUL AABEL,
DEDING AAGE,
ERIKSEN JAN,
MEJER JOHANNES
Publication year - 1980
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1980.tb00110.x
Subject(s) - purine nucleoside phosphorylase , common variable immunodeficiency , 5' nucleotidase , purine , lymphocyte , nucleotidase , immunology , immunodeficiency , primary immunodeficiency , nucleoside , medicine , biology , antibody , chemistry , enzyme , biochemistry , immune system
The results of immunological and purine enzyme investigations in an adult male patient with common variable immunodeficiency, recurrent lymph node granuloma and splenomegaly are presented. Serum immunoglobulins were present in trace amounts only and a progressive loss of Ig‐bearing peripheral lymphocytes were demonstrated. Furthermore, the mitogenic responses to PHA, ConA and PWM were markedly reduced and the ratio of T. m /T. g cells was decreased. Finally, a combined deficiency of lymphocyte purine 5‐nucleotidase‐ and nucleoside phosphorylase was demonstrated in the patient.