Premium
PREGNANCY SPECIFIC BETA‐1 GLYCOPROTEIN (SP1) IN PATIENTS WITH TROPHOBLASTIC DISEASE: MOLECULAR HETEROGENEITY AND A »SP1 CONSUMING FACTOR«
Author(s) -
WESTERGAARD J. G.,
SIZARET PH.,
HINDERSSON P.,
FOLKERSEN J.,
TEISNER B.
Publication year - 1980
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1980.tb00099.x
Subject(s) - glycoprotein , disease , immunoelectrophoresis , pregnancy , antiserum , trophoblast , medicine , choriocarcinoma , beta (programming language) , immunology , antibody , biology , microbiology and biotechnology , placenta , genetics , fetus , computer science , programming language
The reactivity of sera from 19 patients with trophoblastic disease was analyzed in analytic immunoelectrophoresis using rabbit anti human pregnancy specific beta‐1 glycoprotein (SP1) antisera. Molecular heterogeneity of SP1 was demonstrated in crossed immunoelectrophoresis and a »SP1 consuming factors« was found in serum from a patient with choriocarcinoma. The »SP1 consuming factor« was precipitated by 1.65 M (NH 4 ) 2 SO 4 . The results are discussed in relation to quantification of circulating SP1 in patients with trophoblastic disease.