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ANTIBODY RESPONSE IN PATIENTS WITH PSEUDOMONAS AERUGINOSA INFECTION TO A ‘COMMON ANTIGEN’ FROM P. AERUGINOSA ANALYSED BY MEANS OF QUANTITATIVE IMMUNOELECTROPHORETIC METHODS
Author(s) -
HØIBY N.,
HERTZ J. B.,
SOMPOLINSKY D.
Publication year - 1980
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1980.tb00088.x
Subject(s) - pseudomonas aeruginosa , antibody , antigen , immunoelectrophoresis , microbiology and biotechnology , antibody response , immunology , bacteria , biology , virology , medicine , genetics
381 sera from 101 patients suffering from Pseudomonas aeruginosa infection have been investigated for antibodies against a ‘common antigen’ (CA) and other antigens from P. aeruginosa by means of crossed immunoelectrophoresis with intermediate gel, using a polyspecific P. aeruginosa antigen/antibody reference system. The earliest antibody response during the P. aeruginosa infections included increased CA antibodies in only 38% of the patients examined. The peak level of the antibody response included increased CA antibodies in 71% of the patients. By means of ‘absorption of antibodies in situ ’, it was found that the antibody response to CA was directed against both the common cross‐reactive part of the CA molecule and the Pseudomonas ‐specific part, with individual variations. During infections caused by other bacteria containing CA, one‐third of the patients developed antibodies against CA. The diagnostic implications of the results are discussed.