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Trisodium Phosphonoformate Inhibits Hepatitis B Dane Particle Dna Polymerase
Author(s) -
Nordenfelt Erik,
Helgstrand E.,
öberg B.
Publication year - 1979
Publication title -
acta pathologica microbiologica scandinavica section b microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-131X
DOI - 10.1111/j.1699-0463.1979.tb02406.x
Subject(s) - virology , polymerase , dna polymerase , dna , microbiology and biotechnology , chemistry , medicine , biology , genetics
Evidence available indicates that the so‐called Dane particles are the hepatitis virus. A DNA polymerase is associated with the core of these particles. The probability that this is the viral DNA polymerase offers the possibility of preventing hepatitis B multiplication by selective inhibition of this enzyme. This investigation reports that trisodium phosphonoformate (PFA) at low concentrations but not phosphonoacetate acid (PAA) inhibits Dane particle associated DNA polymerase.