Premium
MORPHOLOGY AND FUNCTION OF THE GASTRIC MUCOSA IN FIRST‐DEGREE RELATIVES OF PROBANDS WITH HISTOLOGICALLY DIFFERENT TYPES OF GASTRIC CARCINOMA
Author(s) -
IHAMÄKI TIMO,
SIPPONEN PENTTI
Publication year - 1979
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1979.tb00077.x
Subject(s) - proband , intestinal metaplasia , antrum , medicine , first degree relatives , gastroenterology , gastritis , cancer , gastric mucosa , atypia , atrophic gastritis , gastrin , population , stomach , family history , pathology , biology , mutation , gene , genetics , environmental health , secretion
The occurrence of antral and body gastritis, the prevalence of intestinal metaplasia (IM), epithelial atypia (EA) and circulating antibodies, and the maximal acid output (MAO) and fasting serum gastrin level (FSG) were studied in 301 first‐degree relatives of probands with histologically different types of gastric carcinoma: Intestinal (IC), diffuse spreading (DC) and anaplastic (AC). The results were compared with those obtained from a similar study of 358 first‐degree relatives of probands age and sex matched by computer for each cancer proband from a large Finnish population. The mean score of gastritis changes, the prevalence of atrophic gastritis of antrum and body, of IM, and the mean FSG were significantly higher and the mean MAO significantly lower in DC relatives than in their controls. No such differences were found between IC relatives and controls. The results suggest that there is a genetic or familial association of chronic gastritis with DC but not with other gastric cancer types.