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THE DISTRIBUTION OF LYSOZYME IN HUMAN GASTRIC MUCOSA IN INFLAMMATORY AND NEOPLASTIC DISORDERS
Author(s) -
REITAMO S.,
REITAMO J. J.,
SIPPONEN P.,
KLOCKARS M.
Publication year - 1979
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1979.tb00076.x
Subject(s) - immunoperoxidase , lysozyme , pathology , intestinal metaplasia , gastric mucosa , stomach , staining , adenocarcinoma , metaplasia , biology , medicine , gastroenterology , immunology , cancer , biochemistry , antibody , monoclonal antibody
An immunoperoxidase staining technique was used to identify lysozyme (LZM) in glutaraldehyde‐fixed paraffin‐embedded tissue sections obtained from patients operated on for a gastric or duodenal ulcer or for a neoplasm of the stomach. As in normal gastric mucosa, LZM was identified in neutrophilic granulocytes, in cells belonging to the mononuclear phagocytic system and in gastric glands. LZM was also identified in metaplastic Paneth cells in islands of intestinal metaplasia. In only one patient, who had a moderately‐differentiated gastric adenocarcinoma, was LZM present in neoplastic glands. Tumour tissue however contained various numbers of LZM‐positive macrophages. Based on the present knowledge of LZM function we conclude that its presence in gastric secretions accords with a definite role of LZM in the nonspecific host defence against exogenous microorganisms. The significance of its presence in tumour associated macrophages needs further studies.