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NUTRITIONALLY INDUCED NECROTIZING GLOMERULONEPHRITIS AND POLYARTERITIS NODOSA IN PIGS
Author(s) -
ELLING FOLMER
Publication year - 1979
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1979.tb00067.x
Subject(s) - mesangium , polyarteritis nodosa , basement membrane , pathology , glomerular basement membrane , glomerulonephritis , necrosis , immunofluorescence , lesion , glomerulus , podocyte , electron microscope , necrotizing vasculitis , biology , chemistry , medicine , kidney , vasculitis , immunology , endocrinology , proteinuria , antibody , disease , physics , optics
A florid necrotizing glomerulonephritis was found in all 48 pigs that were fed a waste product from the industrial production of the proteolytic enzyme Alcalase® NOVO. In addition, three of the animals developed a lesion identical to polyarteritis nodosa. Focal necrosis of the glomeruli was observed in all animals. Electron microscopy showed electron dense deposits at the subendothelial and subepithelial side of the basement membrane of the glomerular capillary wall and in the mesangium. Immunofluorescence microscopy showed IgM in a fine granular pattern in the glomeruli of all 48 pigs. This appears to be the first report on nutritionally induced glomerulonephritis and polyarteritis nodosa in pigs.