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FORMATION OF GRANULATION TISSUE IN SUBCUTANEOUSLY IMPLANTED SPONGES IN RATS
Author(s) -
HØLUND B.,
JUNKER P.,
GARBARSCH C.,
CHRISTOFFERSEN P.,
LORENZEN I.
Publication year - 1979
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1979.tb00064.x
Subject(s) - granulation tissue , sponge , calcification , implant , granulation , chemistry , staining , anatomy , histology , biomedical engineering , wound healing , pathology , materials science , surgery , medicine , biology , composite material , botany
A comparison was made between the granulation tissue formation in two different synthetic sponge types, Visella and Ivalon, of different sizes. The granulation tissue formed in the two sponge types did not differ qualitatively, and had the character of wound tissue and inflammatory tissue in man. The rate of tissue formation in the Visella sponges was faster and the tissue was more homogenous than in the Ivalon sponges. Fourteen‐day‐old Visella implants of either size contained more granulation tissue than Ivalon sponges, probably owing to the smaller pore size of the former material. This may also account for the more frequent occurrence of giant cells in the Visella inplants. In contrast to the Visella sponges, the trabeculae of the Ivalon polymer showed calcification and positive staining properties with histological staining procedures, and deformation was frequent among the Ivalon implants. Thin sponges of either type closed in about 21 days, thick ones after about 42 days of implantation. Calculated per 2 cm 3 of implant, thin sponges produced more tissue after 14 days of implantation than thick ones. It is concluded that the Visella sponge type is best suitable for this experimental model of inflammation.