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TERATOGENICITY OF INTRAUTERINE COPPER WIRE IN MICE
Author(s) -
RASMUSSEN B. BRUUN,
CHRISTENSEN N.
Publication year - 1979
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1979.tb00051.x
Subject(s) - growth retardation , pregnancy , fetus , medicine , fetal death , obstetrics , intrauterine death , andrology , gynecology , physiology , biology , genetics
Immediately after the implantation of the fertilized ovum, on the 6th day of pregnancy, a copperwire was placed in the right hand uterine section on pregnant C3H mice. The left section was similarly surgically traumatized in order to serve as a control. The mice were killed with chloroform on the 19th day of pregnancy and by means of a special histological screening technique the fetuses were examined with special reference to growthreduction, intrauterine fetal death and microscopic malformations. Differences in intrauterine fetal death were shown not to exist, nor was there any significant growthretardation in the copperwire containing uterine section. Certain microscopic defects were found with slightly increased incidence in the copper containing section, but the differences were not statistically significant.