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STRUCTURAL CHANGES AND ABILITY TO RELEASE RENIN IN AUTO‐ AND ALLOTRANSPLANTS OF MOUSE SUBMAXILLARY GLANDS
Author(s) -
FAARUP POUL,
BING JENS
Publication year - 1979
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1979.tb00044.x
Subject(s) - autotransplantation , renin–angiotensin system , submaxillary gland , medicine , endocrinology , transplantation , chemistry , blood pressure
In mice having a high renin content in the submaxillary glands allo‐ and autotransplantation of the gland showed identical histological changes of the tissue, comprising disappearance of acini and intercalated ducts as well as a reduction in the number and size of granules in the granulated ducts. No structural signs of rejection were found. Adenomas, possibly originating in the granulated ducts, were frequently present in the transplanted glands. The renin content of autotransplanted glands was invariably much higher than in allotransplants, and after noradrenaline injection renin was released only from autotransplants, never from allotransplants. Blockade of the renin system was accordingly followed by a decrease in blood pressure only in mice with autotransplants.