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INFLUENCE OF SURFACE LIPIDS ON SKIN CARCINOGENESIS IN RATS
Author(s) -
ARFFMANN E.,
HJØRNE N.
Publication year - 1979
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1979.tb00035.x
Subject(s) - dmba , carcinogen , carcinogenesis , chemistry , latency stage , anthracene , pyrene , medicine , biochemistry , cancer , photochemistry , organic chemistry
Skin tumours were induced in female Wistar SPF‐rats by different polycyclic aromatic hydrocarbons, benzo[α]pyrene (BP), dibenz[α, h]anthracene (DBA), 7,12‐dimethylbenz[α]anthracene (DMBA), and 3‐methylcholanthrene (MCA) being applied on the dorsal skin of 20 rats each. DBA was not carcinogenic under the experimental conditions. DMBA proved the most potent carcinogen, and MCA was more potent than BP. Half of the animals in each group underwent skin‐surface lipid extraction (SSLE) before the application of carcinogen. SSLE did not influence the cumulative number of rats with skin tumours during an observation period of 15 months nor the type of tumours induced. The lipid extraction, however, increased the latency period and decreased the rate of tumour development when BP and MCA acted as carcinogens. On the contrary, SSLE enhanced the rate of tumour production by DMBA and reduced the latency period. The role of sebum and its composition in skin carcinogenesis is discussed, and an explanation of the different influence of SSLE on BP and MCA carcinogenesis in contrast to DMBA carcinogenesis is sought in differences in metabolic activation of the carcinogens.