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ASCITES TUMORS IN CBA MICE
Author(s) -
RYD WALTER,
HAGMAR BJÖRN
Publication year - 1979
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1979.tb00030.x
Subject(s) - ascites , pathology , fibrosarcoma , ultrastructure , tumor cells , cell , biology , chemistry , cancer research , medicine , genetics
We have studied four syngeneic murine tumors, a fibrosarcoma, a squamous cell carcinoma and their two ascites‐converted counterparts, by transmission electron microscopy. The ascites tumors were investigated both as cell suspension (AA‐tumor) and as solid tumor (AS‐tumor). We have also studied the ascites tumors, enzymatically produced cell suspensions of the AS‐tumors and solid original tumors by scanning electron microscopy. The two ascites tumors are totally de‐differentiated and lack intercellular junctions. This, we think, is a prerequisite for ascites growth. But the ascites tumors show no peculiar ultrastructural features in comparison with other undifferentiated malignant tumors. We found no morphological cell alterations by the enzymatical dissociation procedure used to bring the solid tumors into suspension. Differences between the AS and AA tumors can be ascribed to differences in proliferation rates.