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CARCINOMA‐IN‐SITU OF TESTIS IN TESTICULAR FEMINIZATION SYNDROME
Author(s) -
SkakkebaeoEk Niels E.
Publication year - 1979
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1979.tb00028.x
Subject(s) - testicular feminization , gonad , abnormality , germ cell , feminization (sociology) , biology , pathology , androgen insensitivity syndrome , carcinoma in situ , testicle , endocrinology , carcinoma , medicine , genetics , cancer , social science , androgen receptor , prostate cancer , psychiatry , sociology , gene
A light microscopical study of an excised testis from a 14 1/2‐year‐old girl with incomplete type of testicular feminization syndrome revealed a carcinoma‐in‐situ pattern in a part of the gonad. An identical histological pattern has repeatedly been demonstrated in infertile men who developed gross testicular germ cell tumours. It is suggested that germ cell carcinomas in patients with testicular feminization syndrome may be preceded by this characteristic intratubular germ cell abnormality.