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LYMPHOCYTE SUBPOPULATIONS IN MAN. EXPRESSION OF HLA‐DR DETERMINANTS ON HUMAN T CELLS IN INFECTIOUS MONONUCLEOSIS
Author(s) -
Johnsen H. E.,
Madsen M.,
Kristensen T.,
KissmeyerNielsen F.
Publication year - 1978
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1978.tb02595.x
Subject(s) - mononucleosis , immunology , human leukocyte antigen , lymphocytosis , t lymphocyte , antigen , biology , virology , population , hla dr , t cell , medicine , immune system , virus , environmental health
In a study of lymphocyte subpopulations in peripheral blood during infectious mononucleosis the lymphocytosis was found to be of T‐cell origin (i.e. E‐RFC), while the number of non T lymphocytes (i.e. EA‐, EAC‐RFC and Smlg + ve cells) was normal in 7 out of 8 patients. Ten patients were tested for the presence of HLA‐DR determinants on their B and T cells and not only B lymphocytes but also a great part (31–75 96) of T cells were lysed by the anti HLA‐DR testsera, indicating that HLA‐DR determinants are expressed on a population of T cells in IM patients. After recovery all patients were retested and showed a normal pattern of HLA‐DR typing. This indicates an increase of HLA‐DR antigens on T cells or a vigorous proliferation of a small DR‐positive T‐cell subpopulation during the acute stage of IM.