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INFLUENCE OF PHENYLBUTAZONE ON LEUKOCYTE CHEMILUMINESCENCE AND FUNCTION
Author(s) -
Solberg Claus O.,
Allred Craig D.,
Hill Harry R.
Publication year - 1978
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1978.tb02575.x
Subject(s) - chemiluminescence , phagocytosis , phenylbutazone , intracellular , sodium azide , chemistry , opsonin , luminol , in vivo , myeloperoxidase , phagocyte , granulocyte , pharmacology , immunology , biochemistry , inflammation , biology , chromatography , microbiology and biotechnology
The effect of phenylbutazone on human leukocyte chemiluminescence, phagocytosis and intracellular killing of bacteria has been examined. A marked reduction of chemiluminescence and intracellular killing of bacteria was observed. The effect on phagocytosis was less pronounced. High drug concentrations nearly abolished light emission, and concentrations equivalent to those obtained in plasma during therapy caused a 25–30% reduction. The effect occurred within less than 10 minutes. No permanent effect upon resting cells was observed. Phenylbutazone reduced the effect of sodium azide on leukocyte chemiluminescence, indicating that the drug might also inhibit myeloperoxidase dependent chemiluminescence. Whether these impairments of leukocyte function also take place in vivo resulting in enhanced susceptibility to infection remains unknown.