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IS THE DIABETOGENIC EFFECT OF STREPTOZOTOCIN IN PART THYMUS‐DEPENDENT?
Author(s) -
Buschard Karsten,
Rygaard JøRgen
Publication year - 1978
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1978.tb02552.x
Subject(s) - streptozotocin , diabetes mellitus , immune system , medicine , endocrinology , immunology
Following a single injection of 200 mg streptozotocin/kg BW, 25 out of 25 normal mice became diabetic, whereas 12 (= 20%) out of 59 athymic nude mice did not develop diabetes. In a multiple dosage experiment, where the same total dose was given over a 5 days period, 14 normal and 15 athymic nude mice all became diabetic, but nude mice had significantly lower blood glucose values. These results support our previous suggestion that a thymus dependent immune reaction is, in part, responsible for the diabetogenic effect of streptozotocin.