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THE PREVALENCE AND POSSIBLE SIGNIFICANCE OF IgD GRANULOCYTE‐SPECIFIC ANTINUCLEAR ANTIBODIES IN NEUTROPENIC AND NON‐NEUTROPENIC CASES OF RHEUMATOID ARTHRITIS
Author(s) -
Wiik Allan,
Permin Henrik
Publication year - 1978
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1978.tb02551.x
Subject(s) - medicine , rheumatoid arthritis , leukopenia , anti nuclear antibody , immunoglobulin d , neutropenia , immunology , antibody , autoantibody , chemotherapy , b cell
Sera from 21 rheumatoid arthritis patients with accompanying neutropenia (2000 neutrophils/μ1) and 45 rheumatoid arthritis patients without neutropenia were studied for the occurrence of IgD granulocyte‐specific antinuclear antibodies. Such antibodies were found in 67 per cent of the neutropenic and 18 per cent of the non‐neutropenic cases (p<0.001). The titres of IgD granulocyte‐specific antinuclear antibodies varied independently of the titres of IgD and complement‐fixing granulocyte‐specific antinuclear antibodies, but showed some covariation with granulocyte‐specific antinuclear antibodies of the IgA and IgM classes most probably reflecting a broad polyclonal antibody response to phagocyte nuclear antigens in the serologically highly active neutropenic cases. Gel filtration studies on selected sera containing IgD granulocyte‐specific antinuclear antibodies indicated participation of these antibodies in immune complexes. It is thus possible that IgD granulocyte‐specific antinuclear antibodies may have some significance for the rheumatoid inflammatory processes.