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EFFECT OF HUMAN LEUKOCYTE INTERFERON ON THE PERMEABILITY OF THE CYTOPLASMA MEMBRANE OF CULTURED CELLS
Author(s) -
DEGRÉ MIKLOS
Publication year - 1978
Publication title -
acta pathologica microbiologica scandinavica section b microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-131X
DOI - 10.1111/j.1699-0463.1978.tb00048.x
Subject(s) - permeability (electromagnetism) , cytoplasm , membrane , chemistry , interferon , microbiology and biotechnology , biophysics , immunology , biology , biochemistry
The effect of human leukocyte interferon on the cytoplasma membrane of cultured homologous cells has been investigated. U‐amnion cells were labelled with (1‐ 14 C) alpha‐aminoisobutyric acid (AIB), a low‐molecular‐weight non‐metabolizable amino acid. Following uptake, the AIB is released spontaneously from the cells. Treatment of cells with interferon reduced the AIB release. This effect was dosedependent, was neutralized by anti‐interferon serum and was strongly reduced by trypsin treatment.