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EFFECTS OF THE NONAPEPTIDE SQ 20.881 ON THE BLOOD PRESSURE OF CONSCIOUS NORMOTENSIVE AND CHRONIC HYPERTENSIVE MICE
Author(s) -
Svendsen Ulrik Gerner
Publication year - 1977
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1977.tb03911.x
Subject(s) - blood pressure , medicine , angiotensin ii , endocrinology , chronic hypertension , angiotensin converting enzyme , renin–angiotensin system , biology , pregnancy , preeclampsia , genetics
Prevention of conversion of angiotensin I to angiotensin II by means of a converting enzyme inhibitor, the nonapeptide SQ 20.881, in chronic hypertensive mice was followed by a drop in blood pressure in all mice independent of the ethiology of hypertension; in conscious normotensive mice was observed a significant decrease in blood pressure, which, however, was less than that observed in the hypertensive mice.