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CONCANAVALIN A‐INDUCED ACTIVATION OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS MEMORY LYMPHOCYTES INTO SPECIFICALLY CYTOTOXIC T CELLS
Author(s) -
Marker Ole,
Thomsen Allan Randrup,
Andersen Grethe Thörner
Publication year - 1977
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1977.tb03673.x
Subject(s) - lymphocytic choriomeningitis , cytotoxic t cell , effector , concanavalin a , spleen , cytotoxicity , biology , in vitro , immunology , virology , virus , microbiology and biotechnology , biochemistry
When spleen cells, which have been primed to Lymphocytic Choriomeningitis (LCM) virus during a primary infection several months previously, are stimulated in vitro with Con A, highly specific secondary cytotoxic effector cells are generated. The degree of cytotoxicity revealed by such Con A‐stimulated cells is higher than that of non‐incubated spleen cells harvested nine days following the primary infection, and the effect is totally inhibited by anti‐theta serum plus complement treatment of the effector cells immediately before the cytotoxic test.