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ANTIBODY‐DEPENDENT CELL‐MEDIATED CYTOTOXICITY BY ACTIVATED THYMOCYTE POPULATIONS
Author(s) -
Rubin Bent,
HøoierMadsen M.
Publication year - 1977
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1977.tb03641.x
Subject(s) - thymocyte , effector , cytotoxic t cell , antibody , biology , cytotoxicity , microbiology and biotechnology , cell , immunology , macrophage , t cell , immune system , biochemistry , in vitro
The results of the present experiments have shown that activated thymocyte populations are endowed with a cytotoxic potential against antibody‐coated target cells. The effector cells could be divided into at least two subpopulations: 1) host‐derived macrophage‐like cells and 2) thymocyte‐derived donor cell T lymphocytes. These two subpopulations could be separated and identified by means of commonly used immunofractionation techniques. Such data show that effector cells which kill antibody‐coated target cells may be of T cell nature.