Premium
INTERACTIONS OF IMMUNE COMPLEXES AND PLATELETS IN RABBITS IMMUNIZED WITH HAPTEN‐CARRIER CONJUGATES
Author(s) -
Kekomäki Riitta,
Kauppinen HannaLeena,
Penttinen Kari,
Myllylä Gunnar
Publication year - 1977
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1977.tb03632.x
Subject(s) - hapten , aspirin , platelet , conjugate , immune system , antigen , chemistry , immunology , antibody , pharmacology , biochemistry , medicine , mathematical analysis , mathematics
The thrombopenic effects of immune complexes were studied in 32 rabbits, immunized actively with aspirin. The test animals were exposed to hapten‐protein conjugates with a hapten density ranging from 0.6 to 38, and to pure hapten. The resulting thrombopenia and leucopenia correlated closely with the presence of immune complexes in the serum as detected by the platelet aggregation sedimentation pattern test (P1.A.). This platelet‐aggregation activity sedimented mainly in the 19S fraction. The effects induced by polyvalent antigens where dose‐dependent and could be modified by a prior injection of aspirin. Expectedly, monovalent antigens were only marginally effective.