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ANTIBODIES AGAINST PSEUDOMONAS AERUGINOSA IN SERUM FROM NORMAL PERSONS AND PATIENTS COLONIZED WITH MUCOID OR NON‐MUCOID PSEUDOMONAS AERUGINOSA: RESULTS OBTAINED BY CROSSED IMMUNOELECTROPHORESIS
Author(s) -
HØiby Niels
Publication year - 1977
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1977.tb03623.x
Subject(s) - precipitin , pseudomonas aeruginosa , immunoelectrophoresis , antigen , microbiology and biotechnology , antibody , respiratory tract , medicine , biology , immunology , respiratory system , bacteria , genetics
Serum from 154 normal persons was investigated for precipitating antibodies against P. aeruginosa by crossed immunoelectrophoresis, using a polyvalent P. aeruginosa standard antigen. Ninety‐four per cent of the sera contained no demonstrable precipitins, and 6 per cent contained precipitins against only one P. aeruginosa antigen. Thirty‐four per cent of sera from 122 patients colonized with P. aeruginosa , in various anatomical regions contained precipitins against 2 to 41 P. aeruginosa antigens. Serum from 14 patients harbouring mucoid strains of P. aeruginsa contained precipitins against these bacteria, and the average number of precipitins was significantly higher than the average number of precipitins in serum from patients harbouring non‐mucoid strains. The largest number of precipitins was found in serum from adult patients chronically colonized with mucoid P. aeruginosa in the lower respiratory tract, and from adult patients with P. aeruginosa bacteraemia originating from suppurative urinary tract infections cavised by mucoid strains. Serum from patients with P. aeruginosa cystitis or from patients with P. aeruginosa colonization of the middle ear or with wound infection, contained only few or no precipitins.